报告题目：Defects on Biomembrane Enhance Spontaneous Lipid Transfer Rate and Hydrophobic Interactions

报告人：美国康涅狄格大学材料科学研究所Mu-Ping Nieh, Ph.D.

报告时间：2018年1月4日下午15:00

报告地点：实验一楼第一会议室

联系人：江浩教授

报告人介绍

CONTACT INFORMATION 

Department of Chemical & Biomolecular Engineering (CBE)/Department of Biomedical Engineering (BME)/Institute of Materials Science (IMS), University of Connecticut (UCONN), Storrs, CT 06269, USA Tel: 860-486-8708 Email: mu-ping.nieh@uconn.edu 

EDUCATION 

1991 – 1998 Ph.D.  University of Massachusetts, Amherst Chemical Engineering/Polymer Science        & Engineering  

1985 – 1989 B.Sc.  National Taiwan University (NTU), Taipei Chemical Engineering 

APPOINTEMENTS

2010 – now   Associate Professor  UCONN

2007– 2010   Associate Research Officer National Research Council, Canada (NRC) –        Canadian  Neutron Beam Centre (CNBC) 

2005 – 2007  Assistant Research Officer NRC-CNBC

2004 – 2005  Research Associate   NRC-CNBC/ University of Guelph

2001 – 2004  Visiting Fellow   NRC-CNBC, Chalk River Laboratories

1998 – 2001  Postdoctoral    National Institute of Standards & Technology (NIST)             Researcher   / Penn. State Univ. (PSU) 

ACHIEVEMENTS  

1. Organizing “Metrology of Characterization, Simulation & Theory of Biomembranes” symposium at American Chemical Society (ACS) national meeting (2015 Fall) and co-organizing “Biomembrane Synthesis, Structure, Mechanics, & Dynamics” symposium at the ACS national meeting since 2014

2. Organizing Focus Sessions “Structures and Dynamics of Biomimetic Membranes” at the American Physical Society (APS) Annual Meeting (2012, 2013) 

3. Designing and constructing Canadian first small angle neutron scattering (SANS) instrument based on the configuration of Triple-Axis Neutron Scattering Spectrometer 

4. Supervised 15 graduate and > 20 undergraduate students 5. Initiating a webinar about “small angle X-ray scattering” at UCONN for industrial researchers 

EXPERIENCES 

Research:

1. Designing self- and directed- assemblies to probe the structure-function relationship of soft nanomaterial composed of polymers, lipids, surfactants and proteins under various environments (controlled temperature, salinity, humidity) and geometries (thin films, porous media). 

2. Investigating kinetics of reaction- and diffusion- limited aggregation processes as well as spontaneous lipid transfer mechanism. 

3. Establishing the spontaneous structural diagram of magnetically and mechanically alignable phospholipid mixtures (“bicelles”) in solutions, commonly used as substrates for membrane-associated proteins to study their structures – receiving more than 800 total citations related to the subject 

4. Developing low-cost, high-sensitivity, instrument-free pathogen-, cell- or toxin- detecting technology 

5. Formulating active therapeutic/diagnostic liposomes suitable for molecular imaging and treatment of Alzheimer, cancer and other diseases, collaborating with scientists at several institutes at NRC (Institute for biological sciences, Institute for Biodiagnostics and Institute for National Measurement Standards). 

6. Characterizing the morphology of per-fluorinated comb-shaped proton exchange membranes (PEM) for fuel cells 7. Investigating the quenching mechanism of fluorescence-based polymer films for fast explosive detection   

Teaching:  

1. Offering Courses: “Introduction to Chemical Engineering Thermodynamics I & II” (core courses)”, “NanoStructural Characterization” – UCONN and Lanzhou Univ. 

2. Lecturing “Small Angle Neutron Scattering” course at 2013 National Synchrotron Radiation Research Center Neutron Workshop and 2006, 2009, 2013 CNBC summer school  

3. Hosting research sites for training high school students to conduct 4-week research projects at the UCONN Mentor Connection program since 2012 as well as for high/middle school STEM teachers (4weeks) at Joule program (organized by the School of Engineering, SoE, UCONN) since 2015. 

4. Presenting the topic “Principle & Application of Nano-Materials in Biomedical Engineering” for middle and high school teachers at da Vinci Project (organized by SoE, UCONN) since 2013 

EXPERIMENTAL EXPERTISE 

Small Angle Scattering, Diffraction, Reflectometry (Neutron, X-ray and Light), Microscopy (Optical and Electron), Fluorescent Spectroscopy, Nuclear Magnetic Resonance (Solution and Solid-State) 

COMMITTEES  

Editorial board member for Journals, Sci. Rep. (Nature Publishing Group), Chem. Eng. & Proc. Tech., Indian J. Mat. Sci. and SOJ Mat. Sci. & Eng.  

Center for Functional Nanomaterials (CFN) at Brookhaven Nat. Lab. (BNL) Proposal Review Member Reviewing neutron scattering beamtime proposals for NIST Center for Neutron Research, ORNL (Spallation Neutron Source and High Flux Isotope Reactor) and CNBC.  

Grant proposal reviewer for National Science Foundation (NSF)  , National Institute of Health (NIH) and Department of Energy (DoE) 

Reviewer for publications in international prestigious journals e.g., J. Am. Chem. Soc., Angewandte Chemie, Adv. Func. Mater., Adv. Mater., Small, Phys. Rev. Lett. etc.) 

SCIENTIFIC OUTPUT (in APPENDICES) 

Refereed Publications:  89 Total citations: ~ 2250 times (h-index: 25 based on scopus); 0 in press Patents: 2; Book Editing: 1; Invited Talks (after 2000): 71; Book Chapters: 7; Conference Contributions: 89; Project Reports: 5 

AWARDS/FUNDINGS 

2016 – 2019  NSF (CBET-Biomedical Engineering), “Collaborative Research: Advanced Biomanufacturing of Functional Bionanoparticles for Biomedical Engineering Applications” (#1604826) - $ 321,177.00 as a co-PI. 

2016 – 2019  NSF (CBET-Particulate & Multiphase Processes), “(NANO)2: gold nanoclusters in lipid nanodiscoidal bicelles as a potential nanodiagnostic platform: experiment and computer modeling” (#1605971) - $ 369,482.00 as a PI. 

2016 – 2017  UCONN Research Excellent Program, “Scalable One-Pot Theranostic Nanodiscs Formulations for Cancer Targeting” - $ 50,000.00 as a PI. 2015 – 2018  Department of Education (GAANN), “Multi-functional Polymer Based Materials – Derived and Learned from Nature” (P200A150330) - $ 966,713 (including matching fund) as a co-PI.

2015 – 2018  NSF (CBET-Nanobiosensing), “UNS: Signal-Amplification for Instrument-Free, Multiplexed Immunoassay - a Generalized Platform for Biosening” (#1510468) - $ 300,413 as a co-PI. 

2014 – 2015  NSF (CBET-Interfacial Process & Thermodynamics), “EAGER: The Effects of Molecular Architectures on Lipid-Based Nanoparticulate Interaction through Polymer Linkers” (#1433903) - $ 149,992 as a PI. 

2012 – 2014  NSF (MRI-DMR), “MRI: Acquisition of a State-of-the-Art Small Angle X-Ray Scattering (SAXS) Instrument for Research and Education” (#1228817) – $568,398 (Total: $811,997 with 30% cost sharing from UConn) as a PI 2012 – 2014 NSF (CMMI-Nanomanufacturing), “Single-Step Manufacture of Affinity Nanodiscs for Drug Delivery” (#1131587) – $387,249 as a PI 

2012 – 2013  Director’s Award for Faculty Excellence, IMS, UCONN 

2011 – 2012 UConn Faculty Large Grant, “Investigation on structural transformation from nano-discs to unilamellar vesicles” (FRS#443360) - $ 25,156 as a PI 

2008 NRC – Steacie Institute for Molecular Sciences (SIMS) “Significant Partnership” Award 2004 – 2006 AFMNet “Developing monodisperse spontaneous unilamellar vesicles of phospholipid mixtures” – ($ 65,000/ year), as a key researcher

2001 – 2004 Visiting Fellowship, Natural Sciences & Engineering Research Council, Canada ($40,000/year)  

1986 – 1989 3 times of NTU “Book Coupon Awards” (for top 5% academic performance students) 

MEMBERSHIPS 

APS, American Chemical Society, Biophysical Society, Neutron Scattering Society of America, Canadian Association of Physicists, Chemical Institute of Canada, Storrs Chinese Christian Church