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报告人：杨健宾州州立大学教授

题目：Citrate  Biomaterials and Applications

时间：9月20号15:00-16:00

地点：实验一楼大会议室

联系人：屈雪

Abstract

In  recent years, citrate-based biomaterials have become an intense focus of  research in the search of new functional biomaterials for solving unmet medical  problems. Citric acid, historically known as an intermediate in the Krebs cycle,  is a multifunctional, nontoxic, readily available, and inexpensive cornerstone  monomer used in the design of citrate-based biomaterials. In addition to the  convenient citrate chemistry for the syntheses of a number of versatile polymers  that may be elastomeric or mechanically strong and tough, injectable and  photocrosslinkable, and/or tissue adhesive, citric acid also presents inherent  anti-bacterial and anti-clotting characteristics and is able to mediate cellular  energy levels which in turn govern some key cellular events such as cell  differentiation. The above features make citrate biomaterials ideal for a number  of medical applications. All these features make citrate biomaterials promising  and worth further developing. Interestingly, the citrate chemistry endows a  great freedom in the design of imaging-enabled biodegradable polymers and small  molecules, thus greatly expanding the functions and capabilities of the  citrate-based biomaterials. Herein, a methodology for the design and biomedical  applications of multifunctional citrate biomaterials will be discussed.  

Short  biography

Dr.  Yang received his PhD in Polymer Chemistry and Physics in 2002 at Institute of  Chemistry, The Chinese Academy of Science in Beijing. He is currently a full  professor at the Department of Biomedical Engineering, The Pennsylvania State  University. Dr. Yang has published 95 peer-reviewed journal articles, 9 issued  patents, and 8 book chapters. He was a recipient of NSF CAREER Award (2010) and  Outstanding Young Faculty Award of College of Engineering at UTA (2011). Dr.  Yang was elected to the Fellow of American Institute of Medical and Biological  Engineering (AIMBE) (Class of 2016). Dr. Yang serves as an Associate Editor for  the journals “Bioactive Materials” and “Frontiers in Biomaterials” and also  serves as a standing member for NIH “Biomaterials and Biointerfaces” study  section. Dr. Yang is the founding secretary for  (Oversea) Chinese Association for Biomaterials (CAB). He has co-founded a  biotechnology company, Aleo BME, Inc. and is also serving on the medical  advisory board for Acuitive Technologies, Inc.

Name and title:  Jian Yang, Professor of Biomedical Engineering

Institution:  Pennsylvania State University

Tel. No.   +1-814-865-1278

Email:  jxy30@psu.edu

Research  interests:Biomaterials,  Tissue Engineering, Drug Delivery, Cancer Targeting and Imaging,  Biosensing