报告题目：Inspiration from Fluorination:Chemical Biology Approaches to Probe Molecular Recognition Events in Biology

报告人：Prof. William C. K. Pomerantz

报告时间：7月19日（星期四）15:30-17:00

报告地点：实验一楼第一会议室

联系人：刘润辉

报告人介绍：

Biography :

2018 - presentAssociate Professor, University of Minnesota, Twin Cities

2012 - 2018Assistant Professor, University of Minnesota, Twin Cities

2008 - 2012Post Doctorate, University of Michigan

2003 - 2008 Ph.D., University of Wisconsin-Madison, Madison, WI

1998 - 2002B.S., Ithaca College, Ithaca NY

Angew. Chem. Int. Ed.,2017, 56, 6440-44.

ACS Nano, 2017, 11, 5623-32.

Nat. Chem. Biol., 2016, 12, 860-6.

Nat. Protoc., 2016, 11, 1414-27.

Angew. Chem. Int. Ed.,2015, 54, 3735-9.

J. Am Chem. Soc.,2011, 133, 13604-13.

Abstract：

Protein-protein interaction (PPI) inhibitor discovery has proven difficult due to the large surface area and dynamic interfaces.To detect these interactions, the trace amounts of organic fluorine in biology has led scientists to benefit from this bioorthogonality and use fluorine to visualize biological phenomenon by magnetic resonance. In the first part of the talk, I will described our efforts to facilitate the early lead discovery rate of small molecules for PPIs using a rapid protein-based ¹⁹F NMR method for detecting protein-ligand interactions called PrOF NMR. In the second part of the talk, I will describe our molecular design efforts for creating new peptide-based ¹⁹F MRI agents.I will present our research design strategy for developing highly fluorinated polyamides with tunable biological and environmental stability.