报告题目：Controlling protein-surface interactions in blood-material contact: designing for blood compatibility

报告人：McMaster University, Hamilton, Ontario, Canada Prof. John L. Brash

报告时间：10月30日（星期二）10:30-11:30

报告地点：实验18楼 315

联系人：刘润辉

个人简历

1958B.Sc., University of Glasgow

1961Ph.D., University of Glasgow

主要发表论文

Blood., 1988, 9, 47-52

Adv. Funct. Mater., 2017, 27, 1703934

Biomaterials., 2005, 26, 7209-7220

Macromolecules, 1998, 31, 109-115

Biomicrofluidics., 2018, 12, 044101

Acs. Appl. Mater. Inter., 2017, 10, 1440-1449

Adv. Funct. Mater., 2017, 27, 1703934

Blood Rev., 2017, 31, 11-21

摘 要

Blood compatible materials are required for devices such as vascular grafts, coronary stents, and prosthetic heart valves. This presentation will touch on several topics related to blood compatibility. These include plasma protein adsorption, platelet adhesion, protein resistant surfaces, anticoagulant surfaces, and fibrinolytic surfaces. Understanding the behaviour of proteins at interfaces is an important underlying theme of our work, and for a number of years we have followed a 2-point principle for the design of biocompatible surfaces based on controlling protein-surface interactions: (1) preventing nonspecific protein interactions (referred to as “the enemy” of biocompatibility) in contact with blood or tissue, and (2) promoting the specific interactions of target proteins to provide appropriate bioactivity, e.g. anti-bacterial, anti-inflammatory, anti-thrombotic. Examples from our work on blood compatibility include: blended polyethylene oxide (PEO)-polyurethane systems for protein resistance, surfaces with anticoagulant properties and surfaces with clot-lysing properties based on their ability to “capture” proteins of the fibrinolytic system.