报告题目：Biomaterials capable of cell membrane modulation and selective in vivo labeling for drug delivery applications

报告人：Prof. Jianjun Cheng

报告时间：7月24日（星期二）15:30-16:30

报告地点：实验一楼二层大会议室

联系人：刘润辉

报告人介绍

Biography :

2015Full Professor, University of Illinois at Urbana Champaign

2011Associate Professor, University of Illinois at Urbana Champaign

2005Assistant Professor, University of Illinois at Urbana Champaign

2004Post Doctorate, MIT

2001Ph.D., University of California, Santa Barbara

1996M.S., Southern Illinois University

1993B.S., Nankai University

PNAS,2018, 115, 4903-4908. 

J. Am. Chem. Soc.,2018, 140, 1235-1238.

Chem. Soc. Rev.,2017, 46, 6570-6599

Nat. Chem. Biol., 2017, 13, 415-424.

Nat. Commun.,2017, 8, 92.

Nat. Chem., 2017, 9, 614-622.

J. Am. Chem. Soc., 2016, 138, 9498-9507.

Nature,2016, 530, 71-76.

报告介绍

Abstract：

I will present our work around design of helical polypeptides. I will report our design of helical, charged polypeptides, which has shown excellent cell membrane activity. By controlling the hydrogen bonding donor and acceptor properties, we can precisely tune the helicity of polypeptides. I will report the integration of Ring-opening metathesis polymerization and ring-opening polymerization of the amino acid N-carboxyanhydride to allow facile synthesis of amino acid N-carboxyanhydride was found and the polymerization of controlled by the brush polypeptide helices In the second portion of my talk, I will present sugar molecule mediated in vivo Cancer targeting.