报告题目：Protein Engineering of Multi-functional Biomaterials for Regenerative Medicine

报告人：Prof. Sarah C. Heilshorn，Stanford University

报告时间：9月24日（星期一）10:30-11:30

报告地点：实验一楼二层大会议室

联系人：刘润辉

Biography

1998B.Eng., Georgia Institute of Technology

2004Ph.D., California Institute of Technology

2004-2006Postdoctoral Fellow, University of California, Berkeley

2006-2014Assistant Professor, Stanford University

2014-currentAssociate Professor, Stanford University

Honors

2015University of Sydney International Research Collaboration Award

2017Royal Society of Chemistry, elected fellow

2018Young Talent Award, State Key Laboratory of Molecular Engineering of Polymers, China

Nat. Mater,. 2017; 16:1233-1242

Nat. Biotechnol., 2016; 34:752-759

Science, 2010; 327:547-552.

Cell, 2007; 129:565-577.

Adv. Mater., 2009; 21:4148-4152

Adv. Mater., 2012; 24:3923-3940.

Abstract

Stem cell transplantation is a promising therapy for a myriad of debilitating diseases and injuries; however, current expansion and transplantation protocols are inadequate. My lab designs biomaterials to overcome these challenges using biomimetic, protein-engineering technology. By integrating protein science methodologies with simple polymer physics models, we manipulate the polypeptide chain interactions and demonstrate the direct ability to tune the material properties including hydrogel mechanics, cell-adhesion, and biodegradation. These materials have allowed us to identify matrix remodeling as a previously unknown requirement

for maintenance of stemness in neural progenitor cells within 3D expansion systems. Through a series of in vitro and in vivo studies, we demonstrate that protein-engineered hydrogels may significantly improve transplanted stem cell retention and regenerative function. Furthermore, many of the lessons learned about designing injectable biomaterials can be extended to design new bio-inks for 3D printing applications. While 3D printing has enormous potential for tissue engineering, few bio-inks are currently available to facilitate the printing of complex, cell-laden constructs. We demonstrate the design of customizable bio-inks that enable the printing of multiple cell types into distinct geometric forms.